Ontology highlight
ABSTRACT:
SUBMITTER: Tallmadge RL
PROVIDER: S-EPMC4107094 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Developmental and comparative immunology 20140412 2
To further studies of neonatal immune responses to pathogens and vaccination, we investigated the dynamics of B lymphocyte development and immunoglobulin (Ig) gene diversity. Previously we demonstrated that equine fetal Ig VDJ sequences exhibit combinatorial and junctional diversity levels comparable to those of adult Ig VDJ sequences. Herein, RACE clones from fetal, neonatal, foal, and adult lymphoid tissue were assessed for Ig lambda light chain combinatorial, junctional, and sequence diversit ...[more]