Ontology highlight
ABSTRACT:
SUBMITTER: Elcheva I
PROVIDER: S-EPMC4107340 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Nature communications 20140714
Advancing pluripotent stem cell technologies for modelling haematopoietic stem cell development and blood therapies requires identifying key regulators of haematopoietic commitment from human pluripotent stem cells (hPSCs). Here, by screening the effect of 27 candidate factors, we reveal two groups of transcriptional regulators capable of inducing distinct haematopoietic programs from hPSCs: pan-myeloid (ETV2 and GATA2) and erythro-megakaryocytic (GATA2 and TAL1). In both cases, these transcript ...[more]