Ontology highlight
ABSTRACT:
SUBMITTER: Borger DR
PROVIDER: S-EPMC4107454 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Borger Darrell R DR Goyal Lipika L Yau Thomas T Poon Ronnie T RT Ancukiewicz Marek M Deshpande Vikram V Christiani David C DC Liebman Hannah M HM Yang Hua H Kim Hyeryun H Yen Katharine K Faris Jason E JE Iafrate A John AJ Kwak Eunice L EL Clark Jeffrey W JW Allen Jill N JN Blaszkowsky Lawrence S LS Murphy Janet E JE Saha Supriya K SK Hong Theodore S TS Wo Jennifer Y JY Ferrone Cristina R CR Tanabe Kenneth K KK Bardeesy Nabeel N Straley Kimberly S KS Agresta Sam S Schenkein David P DP Ellisen Leif W LW Ryan David P DP Zhu Andrew X AX
Clinical cancer research : an official journal of the American Association for Cancer Research 20140129 7
<h4>Purpose</h4>Mutations in the IDH1 and IDH2 (IDH1/2) genes occur in approximately 20% of intrahepatic cholangiocarcinoma and lead to accumulation of 2-hydroxyglutarate (2HG) in the tumor tissue. However, it remains unknown whether IDH1/2 mutations can lead to high levels of 2HG circulating in the blood and whether serum 2HG can be used as a biomarker for IDH1/2 mutational status and tumor burden in intrahepatic cholangiocarcinoma.<h4>Experimental design</h4>We initially measured serum 2HG con ...[more]