Ontology highlight
ABSTRACT:
SUBMITTER: Acosta A
PROVIDER: S-EPMC4107709 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Acosta Andres A Camilleri Michael M
Therapeutic advances in gastroenterology 20140701 4
Chronic idiopathic constipation is highly prevalent among adults. Bile acids (BAs) and the enterohepatic BA circulation modulate colonic secretion and motility that affect transit. BAs in the colon have a dual action as osmotic and stimulant agents. Newer agents, such as elobixibat (A3309), an inhibitor of the ileal BA transporter, have the potential to improve significantly the management of chronic constipation, with minimal adverse effects. Elobixibat modulates the enterohepatic BA circulatio ...[more]