Predicting aggressive decline in mild cognitive impairment: the importance of white matter hyperintensities.

ABSTRACT:

Importance

Although white matter hyperintensities (WMHs) are associated with the risk for Alzheimer disease, it is unknown whether they represent an independent source of impairment or interact with known markers of disease.

Objective

To examine the degree to which WMHs predict aggressive cognitive decline among individuals with mild cognitive impairment, either independently or by modifying the effects of entorhinal cortex volume (ECV), a marker of Alzheimer disease-related neurodegeneration.

Design, setting, and participants

The Alzheimer's Disease Neuroimaging Initiative is a longitudinal study with 6-month follow-up visits. Three hundred thirty-two participants (mean [SD] age, 74.6 [7.4] years; 118 women) of a total of 374 participants diagnosed as having mild cog

SUBMITTER: Tosto G 

PROVIDER: S-EPMC4107926 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature