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Light-induced release of DNA from gold nanoparticles: nanoshells and nanorods.

ABSTRACT: Plasmon-resonant nanoparticle complexes show highly promising potential for light-triggered, remote-controlled delivery of oligonucleotides on demand, for research and therapeutic purposes. Here we investigate the light-triggered release of DNA from two types of nanoparticle substrates: Au nanoshells and Au nanorods. Both light-triggered and thermally induced release are distinctly observable from nanoshell-based complexes, with light-triggered release occurring at an ambient solution temperature well below the DNA melting temperature. Surprisingly, no analogous measurable release was observable from nanorod-based complexes below the DNA melting temperature. These results suggest that a nonthermal mechanism may play a role in plasmon resonant, light-triggered DNA release.

SUBMITTER: Huschka R

PROVIDER: S-EPMC4108302 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature

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Light-induced release of DNA from gold nanoparticles: nanoshells and nanorods.

Huschka Ryan R Zuloaga Jorge J Knight Mark W MW Brown Lisa V LV Nordlander Peter P Halas Naomi J NJ

Journal of the American Chemical Society 20110720 31

Plasmon-resonant nanoparticle complexes show highly promising potential for light-triggered, remote-controlled delivery of oligonucleotides on demand, for research and therapeutic purposes. Here we investigate the light-triggered release of DNA from two types of nanoparticle substrates: Au nanoshells and Au nanorods. Both light-triggered and thermally induced release are distinctly observable from nanoshell-based complexes, with light-triggered release occurring at an ambient solution temperatur ...[more]

PMID: 21736347

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