Ontology highlight
ABSTRACT:
SUBMITTER: Bhattarai SR
PROVIDER: S-EPMC4108588 | biostudies-literature | 2010 Dec
REPOSITORIES: biostudies-literature
Bhattarai Shanta Raj SR Muthuswamy Elayaraja E Wani Amit A Brichacek Michal M Castañeda Antonio L AL Brock Stephanie L SL Oupicky David D
Pharmaceutical research 20100821 12
<h4>Purpose</h4>To prepare mesoporous silica-based delivery systems capable of simultaneous delivery of drugs and nucleic acids.<h4>Methods</h4>The surface of mesoporous silica nanoparticles (MSN) was modified with poly(ethylene glycol) (PEG) and poly(2-(dimethylamino)ethylmethacrylate) (PDMAEMA) or poly(2-(diethylamino)ethylmethacrylate) (PDEAEMA). The particles were then loaded with a lysosomotropic agent chloroquine (CQ) and complexed with plasmid DNA or siRNA. The ability of the synthesized ...[more]