Ontology highlight
ABSTRACT:
SUBMITTER: Aghili L
PROVIDER: S-EPMC4108616 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Aghili Leila L Foo Jasmine J DeGregori James J De Subhajyoti S
Cell reports 20140501 4
Little is understood about the occurrence of somatic genomic alterations in normal tissues and their significance in the context of disease. Here, we identified potential somatic copy number alterations (pSCNAs) in apparently normal ovarian tissue and peripheral blood of 423 ovarian cancer patients. There were, on average, two to four pSCNAs per sample detectable at a tissue-level resolution, although some individuals had orders of magnitude more. Accordingly, we estimated the lower bound of the ...[more]