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Canine bone marrow stromal cells promote functional recovery in mice with spinal cord injury.


ABSTRACT: Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantation therapy was performed, immediately after the spinal cord was injured. Canine BMSC therapy enhanced functional recovery of the hind limbs in mice with SCI. Nestin-positive cells were observed only in the lesion of mice with SCI that received BMSCs. These results suggest that canine BMSCs promote functional recovery in mice with SCI and that migration of nestin-positive cells may contribute to the efficacy of the BMSC treatment.

SUBMITTER: Oda Y 

PROVIDER: S-EPMC4108777 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature

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Canine bone marrow stromal cells promote functional recovery in mice with spinal cord injury.

Oda Yasutaka Y   Tani Kenji K   Asari Yusuke Y   Quintanilha Luiz Fernando LF   Haraguchi Tomoya T   Momota Yutaka Y   Katayama Masaaki M   Itamoto Kazuhito K   Nakazawa Hiroshi H   Taura Yasuho Y  

The Journal of veterinary medical science 20140221 6


Regenerative therapy has begun to be clinically applied in humans and dogs to treat neurological disorders, such as spinal cord injury (SCI). Here, we show the therapeutic potential of transplantation of cultured canine bone marrow stromal cells (BMSCs) into mice with SCI. Canine BMSC transplantation therapy was performed, immediately after the spinal cord was injured. Canine BMSC therapy enhanced functional recovery of the hind limbs in mice with SCI. Nestin-positive cells were observed only in  ...[more]

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