Ontology highlight
ABSTRACT:
SUBMITTER: Jia K
PROVIDER: S-EPMC4109209 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Jia Kunzhi K Li Lei L Liu Zhihua Z Hartog Matthew M Kluetzman Kerri K Zhang Qing-Yu QY Ding Xinxin X
Drug metabolism and disposition: the biological fate of chemicals 20140606 8
CYP2A13, CYP2B6, and CYP2F1 are neighboring cytochrome P450 genes on human chromosome 19, and the enzymes that they encode overlap in substrate specificity. A CYP2A13/2B6/2F1-transgenic mouse, in which CYP2A13 and 2F1 are both expressed in the respiratory tract and CYP2B6 is expressed in the liver, was recently generated. We generated a CYP2A13 (only) transgenic mouse so that the specific activity of CYP2A13 can be determined. The CYP2B6 and CYP2F1 genes in the CYP2A13/2B6/2F1 genomic clone were ...[more]