Ontology highlight
ABSTRACT:
SUBMITTER: Morgan-Smith M
PROVIDER: S-EPMC4109311 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Morgan-Smith Meghan M Wu Yaohong Y Zhu Xiaoqin X Pringle Julia J Snider William D WD
eLife 20140729
GSK-3 is an essential mediator of several signaling pathways that regulate cortical development. We therefore created conditional mouse mutants lacking both GSK-3α and GSK-3β in newly born cortical excitatory neurons. Gsk3-deleted neurons expressing upper layer markers exhibited striking migration failure in all areas of the cortex. Radial migration in hippocampus was similarly affected. In contrast, tangential migration was not grossly impaired after Gsk3 deletion in interneuron precursors. Gsk ...[more]