Ontology highlight
ABSTRACT:
SUBMITTER: Cingolani F
PROVIDER: S-EPMC4109765 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Cingolani Francesca F Casasampere Mireia M Sanllehí Pol P Casas Josefina J Bujons Jordi J Fabrias Gemma G
Journal of lipid research 20140529 8
Sphingosine kinase inhibitor (SKI) II has been reported as a dual inhibitor of sphingosine kinases (SKs) 1 and 2 and has been extensively used to prove the involvement of SKs and sphingosine-1-phosphate (S1P) in cellular processes. Dihydroceramide desaturase (Des1), the last enzyme in the de novo synthesis of ceramide (Cer), regulates the balance between dihydroceramides (dhCers) and Cers. Both SKs and Des1 have interest as therapeutic targets. Here we show that SKI II is a noncompetitive inhibi ...[more]