Ontology highlight
ABSTRACT:
SUBMITTER: Kim E
PROVIDER: S-EPMC4109796 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20130516 6
Glioblastoma multiforme (GBM) displays cellular hierarchies harboring a subpopulation of stem-like cells (GSCs). Enhancer of Zeste Homolog 2 (EZH2), the lysine methyltransferase of Polycomb repressive complex 2, mediates transcriptional repression of prodifferentiation genes in both normal and neoplastic stem cells. An oncogenic role of EZH2 as a transcriptional silencer is well established; however, additional functions of EZH2 are incompletely understood. Here, we show that EZH2 binds to and m ...[more]