Ontology highlight
ABSTRACT:
SUBMITTER: Liu CM
PROVIDER: S-EPMC4110035 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Liu Cindy M CM Osborne Brendan J W BJ Hungate Bruce A BA Shahabi Kamnoosh K Huibner Sanja S Lester Richard R Dwan Michael G MG Kovacs Colin C Contente-Cuomo Tania L TL Benko Erika E Aziz Maliha M Price Lance B LB Kaul Rupert R
PLoS pathogens 20140724 7
Semen is a major vector for HIV transmission, but the semen HIV RNA viral load (VL) only correlates moderately with the blood VL. Viral shedding can be enhanced by genital infections and associated inflammation, but it can also occur in the absence of classical pathogens. Thus, we hypothesized that a dysregulated semen microbiome correlates with local HIV shedding. We analyzed semen samples from 49 men who have sex with men (MSM), including 22 HIV-uninfected and 27 HIV-infected men, at baseline ...[more]