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The influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in children with non-Hodgkin malignant lymphoma.

ABSTRACT:

Background

We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL).

Patients and methods

In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms.

Results

Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype.

Conclusions

Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTX-related toxicity in children with NHL.

SUBMITTER: Erculj N

PROVIDER: S-EPMC4110085 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

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The influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in children with non-Hodgkin malignant lymphoma.

Erculj Nina N Kotnik Barbara Faganel BF Debeljak Marusa M Jazbec Janez J Dolzan Vita V

Radiology and oncology 20140710 3

<h4>Background</h4>We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL).<h4>Patients and methods</h4>In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms.<h4>Results</h4>Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at h ...[more]

PMID: 25177243

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