Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.
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ABSTRACT:
SUBMITTER: Chorlian DB
PROVIDER: S-EPMC4110722 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Publications
Genetic and neurophysiological correlates of the age of onset of alcohol use disorders in adolescents and young adults.
Chorlian David B DB Rangaswamy Madhavi M Manz Niklas N Wang Jen-Chyong JC Dick Danielle D Almasy Laura L Bauer Lance L Bucholz Kathleen K Foroud Tatiana T Hesselbrock Victor V Kang Sun J SJ Kramer John J Kuperman Sam S Nurnberger John J Rice John J Schuckit Marc M Tischfield Jay J Edenberg Howard J HJ Goate Alison A Bierut Laura L Porjesz Bernice B
Behavior genetics 20130821 5
Discrete time survival analysis was used to assess the age-specific association of event-related oscillations (EROs) and CHRM2 gene variants on the onset of regular alcohol use and alcohol dependence. The subjects were 2,938 adolescents and young adults ages 12-25. Results showed that the CHRM2 gene variants and ERO risk factors had hazards which varied considerably with age. The bulk of the significant age-specific associations occurred in those whose age of onset was under 16. These associatio ...[more]
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