Ontology highlight
ABSTRACT:
SUBMITTER: Thalheimer FB
PROVIDER: S-EPMC4110750 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Thalheimer Frederic B FB Wingert Susanne S De Giacomo Pangrazio P Haetscher Nadine N Rehage Maike M Brill Boris B Theis Fabian J FJ Hennighausen Lothar L Schroeder Timm T Rieger Michael A MA
Stem cell reports 20140619 1
The balance of self-renewal and differentiation in long-term repopulating hematopoietic stem cells (LT-HSC) must be strictly controlled to maintain blood homeostasis and to prevent leukemogenesis. Hematopoietic cytokines can induce differentiation in LT-HSCs; however, the molecular mechanism orchestrating this delicate balance requires further elucidation. We identified the tumor suppressor GADD45G as an instructor of LT-HSC differentiation under the control of differentiation-promoting cytokine ...[more]