Ontology highlight
ABSTRACT:
SUBMITTER: Chinnadurai R
PROVIDER: S-EPMC4110775 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Chinnadurai Raghavan R Garcia Marco A MA Sakurai Yumiko Y Lam Wilbur A WA Kirk Allan D AD Galipeau Jacques J Copland Ian B IB
Stem cell reports 20140606 1
Mesenchymal stromal cells have shown clinical promise; however, variations in treatment responses are an ongoing concern. We previously demonstrated that MSCs are functionally stunned after thawing. Here, we investigated whether this cryopreservation/thawing defect also impacts the postinfusion biodistribution properties of MSCs. Under both static and physiologic flow, compared with live MSCs in active culture, MSCs thawed from cryopreservation bound poorly to fibronectin (40% reduction) and hum ...[more]