Ontology highlight
ABSTRACT:
SUBMITTER: Angelo M
PROVIDER: S-EPMC4110905 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Angelo Michael M Bendall Sean C SC Finck Rachel R Hale Matthew B MB Hitzman Chuck C Borowsky Alexander D AD Levenson Richard M RM Lowe John B JB Liu Scot D SD Zhao Shuchun S Natkunam Yasodha Y Nolan Garry P GP
Nature medicine 20140302 4
Immunohistochemistry (IHC) is a tool for visualizing protein expression that is employed as part of the diagnostic workup for the majority of solid tissue malignancies. Existing IHC methods use antibodies tagged with fluorophores or enzyme reporters that generate colored pigments. Because these reporters exhibit spectral and spatial overlap when used simultaneously, multiplexed IHC is not routinely used in clinical settings. We have developed a method that uses secondary ion mass spectrometry to ...[more]