Ontology highlight
ABSTRACT:
SUBMITTER: Hamadeh IS
PROVIDER: S-EPMC4111800 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Hamadeh I S IS Langaee T Y TY Dwivedi R R Garcia S S Burkley B M BM Skaar T C TC Chapman A B AB Gums J G JG Turner S T ST Gong Y Y Cooper-DeHoff R M RM Johnson J A JA
Clinical pharmacology and therapeutics 20140317 2
Metoprolol is a selective β-1 adrenergic receptor blocker that undergoes extensive metabolism by the polymorphic enzyme cytochrome P450 2D6 (CYP2D6). Our objective was to investigate the influence of CYP2D6 polymorphisms on the efficacy and tolerability of metoprolol tartrate. Two hundred and eighty-one participants with uncomplicated hypertension received 50 mg of metoprolol twice daily followed by response-guided titration to 100 mg twice daily. Phenotypes were assigned based on results of CYP ...[more]