Ontology highlight
ABSTRACT:
SUBMITTER: Sabri A
PROVIDER: S-EPMC4111910 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Sabri Ayoub A Grant Audrey V AV Cosker Kristel K El Azbaoui Safa S Abid Ahmed A Abderrahmani Rhorfi Ismail I Souhi Hicham H Janah Hicham H Alaoui-Tahiri Kebir K Gharbaoui Yasser Y Benkirane Majid M Orlova Marianna M Boland Anne A Deswarte Caroline C Migaud Melanie M Bustamante Jacinta J Schurr Erwin E Boisson-Dupuis Stephanie S Casanova Jean-Laurent JL Abel Laurent L El Baghdadi Jamila J
The Journal of infectious diseases 20140308 4
<h4>Background</h4>Only a minority of individuals infected with Mycobacterium tuberculosis develop clinical tuberculosis. Genetic epidemiological evidence suggests that pulmonary tuberculosis has a strong human genetic component. Previous genetic findings in Mendelian predisposition to more severe mycobacterial infections, including by M. tuberculosis, underlined the importance of the interleukin 12 (IL-12)/interferon γ (IFN-γ) circuit in antimycobacterial immunity.<h4>Methods</h4>We conducted a ...[more]