Ontology highlight
ABSTRACT:
SUBMITTER: Watkins D
PROVIDER: S-EPMC4112084 | biostudies-literature | 2013 Dec
REPOSITORIES: biostudies-literature
Watkins Derrick D Ranjan Nihar N Kumar Sunil S Gong Changjun C Arya Dev P DP
Bioorganic & medicinal chemistry letters 20131101 24
Compounds that stabilize the G-quadruplexes formed by human telomeres can inhibit the telomerase activity and are potential cancer therapies. We have developed an assay for the screening of compounds with high affinity for human telomeric G-quadruplexes (HTG). The assay uses a thiazole orange fluorescent reporter molecule conjugated to the aminoglycoside, neomycin, as a probe in a fluorescence displacement assay. The conjugation of the planar base stacking thiazole orange with the groove binding ...[more]