Ontology highlight
ABSTRACT:
SUBMITTER: Qazilbash MH
PROVIDER: S-EPMC4112362 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Qazilbash Muzaffar H MH Saliba Rima M RM Nieto Yago Y Parikh Gaurav G Pelosini Matteo M Khan Fatima B FB Jones Roy B RB Hosing Chitra C Mendoza Floralyn F Weber Donna M DM Wang Michael M Popat Uday U Alousi Amin A Anderlini Paolo P Champlin Richard E RE Giralt Sergio S
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 20081201 12
Arsenic trioxide (ATO) is synergistic with ascorbic acid (AA) and melphalan against myeloma both in vitro and in vivo. The aim of this randomized phase II trial was to determine the safety and efficacy of a combination of ATO, melphalan, and AA as preparative regimen in 48 patients undergoing autologous hematopoietic stem cell transplantation (ASCT) for multiple myeloma (MM). Forty-eight patients received melphalan 200 mg/m2 i.v. over 2 days and AA 1000 mg i.v. over 7 days in 3 treatment arms: n ...[more]