TGFBR1 and cancer susceptibility.
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ABSTRACT:
SUBMITTER: Pasche B
PROVIDER: S-EPMC4112675 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
TGFBR1 and cancer susceptibility.
Pasche Boris B Pennison Michael J MJ Jimenez Hugo H Wang Minghui M
Transactions of the American Clinical and Climatological Association 20140101
Transforming growth factor beta (TGF-β) is a potent inhibitor of cell growth. TGFBR1 6A is a polymorphism consisting of a 9-base pair in-frame deletion within exon 1 of the type I TGF-β receptor (TGFBR1), which results in a receptor with decreased TGF-β signaling capability. The discovery of an association between TGFBR1*6A and cancer susceptibility led to the hypothesis that hypomorphic variants of the TGF-β signaling pathway may predispose to the development of cancer. This hypothesis was test ...[more]
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