The regional sensitivity of chondrocyte gene expression to coactive mechanical load and exogenous TNF-? stimuli.
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ABSTRACT:
SUBMITTER: Bevill SL
PROVIDER: S-EPMC4112922 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
The regional sensitivity of chondrocyte gene expression to coactive mechanical load and exogenous TNF-α stimuli.
Bevill S L SL Boyer K A KA Andriacchi T P TP
Journal of biomechanical engineering 20140901 9
Both mechanical load and elevated levels of proinflammatory cytokines have been associated with the risk for developing osteoarthritis (OA), yet the potential interaction of these mechanical and biological factors is not well understood. The purpose of this study was to evaluate the response of chondrocytes to the effects of dynamic unconfined compression, TNF-α, and the simultaneous effects of dynamic unconfined compression and TNF-α. The response to these three treatments was markedly differen ...[more]
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