Ontology highlight
ABSTRACT:
SUBMITTER: Aldana-Masangkay GI
PROVIDER: S-EPMC4113006 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Aldana-Masangkay Grace I GI Rodriguez-Gonzalez Agustin A Lin Tara T Ikeda Alan K AK Hsieh Yao-Te YT Kim Yong-Mi YM Lomenick Brett B Okemoto Kazuo K Landaw Elliot M EM Wang Dongpeng D Mazitschek Ralph R Bradner James E JE Sakamoto Kathleen M KM
Leukemia & lymphoma 20110623 8
Over the past decade, histone deacetylase inhibitors have increasingly been used to treat various malignancies. Tubacin (tubulin acetylation inducer) is a small molecule that inhibits histone deacetylase 6 (HDAC6) and induces acetylation of α-tubulin. We observed a higher antiproliferative effect of tubacin in acute lymphoblastic leukemia (ALL) cells than in normal hematopoietic cells. Treatment with tubacin led to the induction of apoptotic pathways in both pre-B and T cell ALL cells at a 50% i ...[more]