Ontology highlight
ABSTRACT:
SUBMITTER: Bogdani M
PROVIDER: S-EPMC4113060 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Bogdani Marika M Johnson Pamela Y PY Potter-Perigo Susan S Nagy Nadine N Day Anthony J AJ Bollyky Paul L PL Wight Thomas N TN
Diabetes 20140327 8
Hyaluronan (HA) is an extracellular matrix glycosaminoglycan that is present in pancreatic islets, but little is known about its involvement in the development of human type 1 diabetes (T1D). We have evaluated whether pancreatic islets and lymphoid tissues of T1D and nondiabetic organ donors differ in the amount and distribution of HA and HA-binding proteins (hyaladherins), such as inter-α-inhibitor (IαI), versican, and tumor necrosis factor-stimulated gene-6 (TSG-6). HA was dramatically increas ...[more]