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Universal area distributions in the monolayers of confluent mammalian cells.

ABSTRACT: When mammalian cells form confluent monolayers completely filling a plane, these apparently random "tilings" show regularity in the statistics of cell areas for various types of epithelial and endothelial cells. The observed distributions are reproduced by a model which accounts for cell growth and division, with the latter treated stochastically both in terms of the sizes of the dividing cells as well as the sizes of the "newborn" ones--remarkably, the modeled and experimental distributions fit well when all free parameters are estimated directly from experiments.

SUBMITTER: Wilk G

PROVIDER: S-EPMC4113185 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Universal area distributions in the monolayers of confluent mammalian cells.

Wilk Gary G Iwasa Masatomo M Fuller Patrick E PE Kandere-Grzybowska Kristiana K Grzybowski Bartosz A BA

Physical review letters 20140401 13

When mammalian cells form confluent monolayers completely filling a plane, these apparently random "tilings" show regularity in the statistics of cell areas for various types of epithelial and endothelial cells. The observed distributions are reproduced by a model which accounts for cell growth and division, with the latter treated stochastically both in terms of the sizes of the dividing cells as well as the sizes of the "newborn" ones--remarkably, the modeled and experimental distributions fit ...[more]

PMID: 24745461

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