Ontology highlight
ABSTRACT:
SUBMITTER: Kim JG
PROVIDER: S-EPMC4113214 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Nature neuroscience 20140601 7
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by lept ...[more]