Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.
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ABSTRACT:
SUBMITTER: Kim JG
PROVIDER: S-EPMC4113214 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding.
Kim Jae Geun JG Suyama Shigetomo S Koch Marco M Jin Sungho S Argente-Arizon Pilar P Argente Jesús J Liu Zhong-Wu ZW Zimmer Marcelo R MR Jeong Jin Kwon JK Szigeti-Buck Klara K Gao Yuanqing Y Garcia-Caceres Cristina C Yi Chun-Xia CX Salmaso Natalina N Vaccarino Flora M FM Chowen Julie J Diano Sabrina S Dietrich Marcelo O MO Tschöp Matthias H MH Horvath Tamas L TL
Nature neuroscience 20140601 7
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by lept ...[more]
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