Ontology highlight
ABSTRACT:
SUBMITTER: Abdel-Aal AB
PROVIDER: S-EPMC4113397 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Abdel-Aal Abu-Baker M AB Lakshminarayanan Vani V Thompson Pamela P Supekar Nitin N Bradley Judy M JM Wolfert Margreet A MA Cohen Peter A PA Gendler Sandra J SJ Boons Geert-Jan GJ
Chembiochem : a European journal of chemical biology 20140530 10
The mucin MUC1 is overexpressed and aberrantly glycosylated by many epithelial cancer cells manifested by truncated O-linked saccharides. Although tumor-associated MUC1 has generated considerable attention because of its potential for the development of a therapeutic cancer vaccine, it has been difficult to design constructs that consistently induce cytotoxic T-lymphocytes (CTLs) and ADCC-mediating antibodies specific for the tumor form of MUC1. We have designed, chemically synthesized, and immu ...[more]