Ontology highlight
ABSTRACT:
SUBMITTER: Goellner EM
PROVIDER: S-EPMC4113420 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20140626 2
Genetic evidence has implicated multiple pathways in eukaryotic DNA mismatch repair (MMR) downstream of mispair recognition and Mlh1-Pms1 recruitment, including Exonuclease 1 (Exo1)-dependent and -independent pathways. We identified 14 mutations in POL30, which encodes PCNA in Saccharomyces cerevisiae, specific to Exo1-independent MMR. The mutations identified affected amino acids at three distinct sites on the PCNA structure. Multiple mutant PCNA proteins had defects either in trimerization and ...[more]