Ontology highlight
ABSTRACT:
SUBMITTER: Xie L
PROVIDER: S-EPMC4113726 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Xie Li L Chen Jing J McMickle Anthony A Awar Nadia N Nady Soad S Sredni Benjamin B Drew Paul D PD Yu Shiguang S
Journal of neuroimmunology 20140607 1-2
We reported that AS101 (organotellurium compound, trichloro(dioxoethylene-O,O') tellurate) inhibited the differentiation of Th17 cells and reduced the production of IL-17 and GM-CSF. In addition, AS101 promoted the production of IL-2 in activated T cells. Flow cytometric analysis showed that AS101 inhibited Th17 cell proliferation. AS101 blocked the activation of transcriptional factor NFAT, Stat3, and RORγt, and increased activation of Erk1/2, suggesting a mechanism of action of AS101. We furth ...[more]