Ontology highlight
ABSTRACT:
SUBMITTER: Eckle SB
PROVIDER: S-EPMC4113946 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Eckle Sidonia B G SB Birkinshaw Richard W RW Kostenko Lyudmila L Corbett Alexandra J AJ McWilliam Hamish E G HE Reantragoon Rangsima R Chen Zhenjun Z Gherardin Nicholas A NA Beddoe Travis T Liu Ligong L Patel Onisha O Meehan Bronwyn B Fairlie David P DP Villadangos Jose A JA Godfrey Dale I DI Kjer-Nielsen Lars L McCluskey James J Rossjohn Jamie J
The Journal of experimental medicine 20140721 8
Mucosal-associated invariant T (MAIT) cells express an invariant T cell receptor (TCR) α-chain (TRAV1-2 joined to TRAJ33, TRAJ20, or TRAJ12 in humans), which pairs with an array of TCR β-chains. MAIT TCRs can bind folate- and riboflavin-based metabolites restricted by the major histocompatibility complex (MHC)-related class I-like molecule, MR1. However, the impact of MAIT TCR and MR1-ligand heterogeneity on MAIT cell biology is unclear. We show how a previously uncharacterized MR1 ligand, acety ...[more]