Impaired DICER1 function promotes stemness and metastasis in colon cancer.
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ABSTRACT:
SUBMITTER: Iliou MS
PROVIDER: S-EPMC4114136 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Publications
Impaired DICER1 function promotes stemness and metastasis in colon cancer.
Iliou M S MS da Silva-Diz V V Carmona F J FJ Ramalho-Carvalho J J Heyn H H Villanueva A A Muñoz P P Esteller M M
Oncogene 20131007 30
Disruption of microRNA (miRNA) expression patterns is now being recognized as a hallmark of human cancer. The causes of these altered profiles are diverse, and, among them, we found the existence of defects in the miRNA processing machinery. However, little is known about how these alterations affect the biology of the underlying tumors. Herein, we show that colorectal cancer cells with an impairment in DICER1, a major miRNA biogenesis gene, undergo enrichment of tumor stemness features and an e ...[more]
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