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Blood compatible carbon nanotubes--nano-based neoproteoglycans.


ABSTRACT: Although nanotechnology has provided a rich variety of nanomaterials (1-100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove that heparinization can significantly enhance the blood compatibility of nanomaterials.

SUBMITTER: Murugesan S 

PROVIDER: S-EPMC4114241 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature

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Blood compatible carbon nanotubes--nano-based neoproteoglycans.

Murugesan Saravanababu S   Park Tae-Joon TJ   Yang Hoichang H   Mousa Shaker S   Linhardt Robert J RJ  

Langmuir : the ACS journal of surfaces and colloids 20060401 8


Although nanotechnology has provided a rich variety of nanomaterials (1-100 nm) for in vivo medical applications, the blood compatibility of all these nanobiomaterials is still largely unexamined. Here, we report the preparation of blood-compatible carbon nanotubes (CNTs) that potentially represent the building blocks for nanodevices having in vivo applications. Activated partial thromboplastin time (APTT) and thromboelastography (TEG) studies prove that heparinization can significantly enhance  ...[more]

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