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Preparation and purification of zinc sulfinate reagents for drug discovery.

ABSTRACT: The present protocol details the synthesis of zinc bis(alkanesulfinate)s that can be used as general reagents for the formation of radical species. The zinc sulfinates described herein are generated from the corresponding sulfonyl chlorides by treatment with zinc dust. The products may be used crude, or a simple purification procedure may be performed to minimize incorporation of water and zinc chloride. Although the synthesis of the zinc sulfinate salts can generally be completed within 3 h, workup can take up to 24 h and purification can take up to 3 h. Following the steps in this protocol would enable the user to generate a small toolkit of zinc sulfinate reagents over the course of 1 week.

SUBMITTER: O'Hara F

PROVIDER: S-EPMC4114315 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature

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Preparation and purification of zinc sulfinate reagents for drug discovery.

O'Hara Fionn F Baxter Ryan D RD O'Brien Alexander G AG Collins Michael R MR Dixon Janice A JA Fujiwara Yuta Y Ishihara Yoshihiro Y Baran Phil S PS

Nature protocols 20130502 6

The present protocol details the synthesis of zinc bis(alkanesulfinate)s that can be used as general reagents for the formation of radical species. The zinc sulfinates described herein are generated from the corresponding sulfonyl chlorides by treatment with zinc dust. The products may be used crude, or a simple purification procedure may be performed to minimize incorporation of water and zinc chloride. Although the synthesis of the zinc sulfinate salts can generally be completed within 3 h, wo ...[more]

PMID: 23640168

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Preparation and purification of zinc sulfinate reagents for drug discovery.

Publications

Preparation and purification of zinc sulfinate reagents for drug discovery.

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