Ontology highlight
ABSTRACT:
SUBMITTER: Johnson CL
PROVIDER: S-EPMC4114557 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Johnson Christopher L CL Ridley Helen H Marchetti Roberta R Silipo Alba A Griffin David C DC Crawford Lucy L Bonev Boyan B Molinaro Antonio A Lakey Jeremy H JH
Molecular microbiology 20140328 3
Colicins are a diverse family of large antibacterial protein toxins, secreted by and active against Escherichia coli and must cross their target cell's outer membrane barrier to kill. To achieve this, most colicins require an abundant porin (e.g. OmpF) plus a low-copy-number, high-affinity, outer membrane protein receptor (e.g. BtuB). Recently, genetic screens have suggested that colicin N (ColN), which has no high-affinity receptor, targets highly abundant lipopolysaccharide (LPS) instead. Here ...[more]