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Molecular effect of ethanol during neural differentiation of human embryonic stem cells in vitro.

ABSTRACT: Potential teratogenic effects of alcohol on fetal development have been documented. Especially studies have demonstrated deleterious effect of ethanol exposure on neuronal development in animal models and on the maintenance and differentiation of neuronal precursor cells derived from stem cells. To better understand molecular effect of alcohol on the process of neural differentiation, we have performed gene expression microarray analysis on human embryonic stem cells being directed to neural rosettes and neural precursor cells in the presence of ethanol treatment. Here we provide detailed experimental methods, analysis and information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE56906. Our data provide scientific insight on potential molecular effects of fetal alcohol exposure on neural differentiation of early embryo development.

SUBMITTER: Kim JJ

PROVIDER: S-EPMC4114725 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Molecular effect of ethanol during neural differentiation of human embryonic stem cells <i>in vitro.</i>

Kim Jeffrey J JJ Duan Lewei L Tu Thanh G TG Elie Omid O Kim Yiyoung Y Mathiyakom Nathan N Elashoff David D Kim Yong Y

Genomics data 20141201

Potential teratogenic effects of alcohol on fetal development have been documented. Especially studies have demonstrated deleterious effect of ethanol exposure on neuronal development in animal models and on the maintenance and differentiation of neuronal precursor cells derived from stem cells. To better understand molecular effect of alcohol on the process of neural differentiation, we have performed gene expression microarray analysis on human embryonic stem cells being directed to neural ros ...[more]

PMID: 25089259

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