Rho GTPases, oxidation, and cell redox control.
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ABSTRACT:
SUBMITTER: Hobbs GA
PROVIDER: S-EPMC4114927 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Rho GTPases, oxidation, and cell redox control.
Hobbs G Aaron GA Zhou Bingying B Cox Adrienne D AD Campbell Sharon L SL
Small GTPases 20140508
While numerous studies support regulation of Ras GTPases by reactive oxygen and nitrogen species, the Rho subfamily has received considerably less attention. Over the last few years, increasing evidence is emerging that supports the redox sensitivity of Rho GTPases. Moreover, as Rho GTPases regulate the cellular redox state by controlling enzymes that generate and convert reactive oxygen and nitrogen species, redox feedback loops likely exist. Here, we provide an overview of cellular oxidants, R ...[more]
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