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Apolipoprotein E gene E2/E2 genotype is a genetic risk factor for vertebral fractures in humans: a large-scale study.


ABSTRACT: PURPOSE: Although many studies have been performed to evaluate whether or not apolipoprotein E gene (APOE) polymorphisms are differentially associated with bone mineral density (BMD) and fractures, the results have been conflicting. This large-scale study was performed to investigate whether a relationship exists between APOE polymorphisms and risk of fracture. METHODS: A hospital-based case-control study was conducted in 3,000 patients with fractures and 3,000 age- and gender-matched healthy controls. Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the APOE gene polymorphisms. RESULTS: Patients with fractures had a significantly higher frequency of APOE E2/E2 genotype [odds ratio (OR)?=?2.02, 95% confidence interval (CI)?=?1.30, 3.14; P?=?0.002] than healthy controls. When stratifying by fracture type, it was found that patients with vertebral fractures had a significantly higher frequency of APOE E2/E2 genotype (OR?=?2.86, 95% CI?=?1.73, 4.73; P?

SUBMITTER: Zhang SQ 

PROVIDER: S-EPMC4115114 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature

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Apolipoprotein E gene E2/E2 genotype is a genetic risk factor for vertebral fractures in humans: a large-scale study.

Zhang Shu Qi SQ   Zhang Wei Ying WY   Ye Wen Qin WQ   Zhang Ling Juan LJ   Fan Fan F  

International orthopaedics 20140601 8


<h4>Purpose</h4>Although many studies have been performed to evaluate whether or not apolipoprotein E gene (APOE) polymorphisms are differentially associated with bone mineral density (BMD) and fractures, the results have been conflicting. This large-scale study was performed to investigate whether a relationship exists between APOE polymorphisms and risk of fracture.<h4>Methods</h4>A hospital-based case-control study was conducted in 3,000 patients with fractures and 3,000 age- and gender-match  ...[more]

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