Ontology highlight
ABSTRACT:
SUBMITTER: Montessuit S
PROVIDER: S-EPMC4115189 | biostudies-literature | 2010 Sep
REPOSITORIES: biostudies-literature
Montessuit Sylvie S Somasekharan Syam Prakash SP Terrones Oihana O Lucken-Ardjomande Safa S Herzig Sébastien S Schwarzenbacher Robert R Manstein Dietmar J DJ Bossy-Wetzel Ella E Basañez Gorka G Meda Paolo P Martinou Jean-Claude JC
Cell 20100901 6
In response to many apoptotic stimuli, oligomerization of Bax is essential for mitochondrial outer membrane permeabilization and the ensuing release of cytochrome c. These events are accompanied by mitochondrial fission that appears to require Drp1, a large GTPase of the dynamin superfamily. Loss of Drp1 leads to decreased cytochrome c release by a mechanism that is poorly understood. Here we show that Drp1 stimulates tBid-induced Bax oligomerization and cytochrome c release by promoting tetheri ...[more]