Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC4115192 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wang Qun Q Zhai Yang-Yang YY Dai Ji-Hong JH Li Kun-Yu KY Deng Qing Q Han Ze-Guang ZG
International journal of biological sciences 20140717 8
Hepatocellular carcinoma (HCC) is a highly malignant cancer with poor prognosis, and driver genes harboring genetic lesions and/or expression dysregulation contribute to hepatocarcinogenesis. Sterile Alpha Motif Domain-containing 9-like (SAMD9L) was a novel identified mutated gene in our previous study on exome sequencing of hepatitis B virus (HBV)-associated HCC, but its expression and role in HCC remain unknown. Here, we demonstrated that SAMD9L was frequently inactivated by somatic mutations, ...[more]