Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery.
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ABSTRACT:
SUBMITTER: Green MD
PROVIDER: S-EPMC4115287 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
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Catch and Release: Photocleavable Cationic Diblock Copolymers as a Potential Platform for Nucleic Acid Delivery.
Green Matthew D MD Foster Abbygail A AA Greco Chad T CT Roy Raghunath R Lehr Rachel M RM Epps Thomas H TH Sullivan Millicent O MO
Polymer chemistry 20140601
Binding interactions between DNA and cationic carriers must be sufficiently strong to prevent nuclease-mediated degradation, yet weak enough to permit transcription. We demonstrate cationic diblock copolymers containing PEG and <i>o</i>-nitrobenzyl moieties that facilitated tailorable DNA complexation and light-activated release. This design unlocks a new approach to advance non-viral gene packaging. ...[more]
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