Ontology highlight
ABSTRACT:
SUBMITTER: Bende NS
PROVIDER: S-EPMC4115291 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Nature communications 20140711
β-Diguetoxin-Dc1a (Dc1a) is a toxin from the desert bush spider Diguetia canities that incapacitates insects at concentrations that are non-toxic to mammals. Dc1a promotes opening of German cockroach voltage-gated sodium (Nav) channels (BgNav1), whereas human Nav channels are insensitive. Here, by transplanting commonly targeted S3b-S4 paddle motifs within BgNav1 voltage sensors into Kv2.1, we find that Dc1a interacts with the domain II voltage sensor. In contrast, Dc1a has little effect on sodi ...[more]