Administration of recombinant soluble urokinase receptor per se is not sufficient to induce podocyte alterations and proteinuria in mice.
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ABSTRACT:
SUBMITTER: Cathelin D
PROVIDER: S-EPMC4116049 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
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Administration of recombinant soluble urokinase receptor per se is not sufficient to induce podocyte alterations and proteinuria in mice.
Cathelin Dominique D Placier Sandrine S Ploug Michael M Verpont Marie-Christine MC Vandermeersch Sophie S Luque Yosu Y Hertig Alexandre A Rondeau Eric E Mesnard Laurent L
Journal of the American Society of Nephrology : JASN 20140501 8
Circulating levels of soluble forms of urokinase-type plasminogen activator receptor (suPAR) are generally elevated in sera from children and adults with FSGS compared with levels in healthy persons or those with other types of kidney disease. In mice lacking the gene encoding uPAR, forced increases in suPAR concentration result in FSGS-like glomerular lesions and proteinuria. However, whether overexpression of suPAR, per se, contributes to the pathogenesis of FSGS in humans remains controversia ...[more]
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