Ontology highlight
ABSTRACT:
SUBMITTER: Yap M
PROVIDER: S-EPMC4116064 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Yap Michelle M Boeffard Françoise F Clave Emmanuel E Pallier Annaick A Danger Richard R Giral Magali M Dantal Jacques J Foucher Yohann Y Guillot-Gueguen Cécile C Toubert Antoine A Soulillou Jean-Paul JP Brouard Sophie S Degauque Nicolas N
Journal of the American Society of Nephrology : JASN 20140320 8
Despite the effectiveness of immunosuppressive drugs, kidney transplant recipients still face late graft dysfunction. Thus, it is necessary to identify biomarkers to detect the first pathologic events and guide therapeutic target development. Previously, we identified differences in the T-cell receptor Vβ repertoire in patients with stable graft function. In this prospective study, we assessed the long-term effect of CD8(+) T-cell differentiation and function in 131 patients who had stable graft ...[more]