Ontology highlight
ABSTRACT:
SUBMITTER: Haynes R
PROVIDER: S-EPMC4116066 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Haynes Richard R Lewis David D Emberson Jonathan J Reith Christina C Agodoa Lawrence L Cass Alan A Craig Jonathan C JC de Zeeuw Dick D Feldt-Rasmussen Bo B Fellström Bengt B Levin Adeera A Wheeler David C DC Walker Rob R Herrington William G WG Baigent Colin C Landray Martin J MJ
Journal of the American Society of Nephrology : JASN 20140501 8
Lowering LDL cholesterol reduces the risk of developing atherosclerotic events in CKD, but the effects of such treatment on progression of kidney disease remain uncertain. Here, 6245 participants with CKD (not on dialysis) were randomly assigned to simvastatin (20 mg) plus ezetimibe (10 mg) daily or matching placebo. The main prespecified renal outcome was ESRD (defined as the initiation of maintenance dialysis or kidney transplantation). During 4.8 years of follow-up, allocation to simvastatin ...[more]