Regulation of Human PAX6 Expression by miR-7.
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ABSTRACT:
SUBMITTER: Needhamsen M
PROVIDER: S-EPMC4116382 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
Regulation of Human PAX6 Expression by miR-7.
Needhamsen Maria M White Robert B RB Giles Keith M KM Dunlop Sarah A SA Thomas Meghan G MG
Evolutionary bioinformatics online 20140714
The paired box gene 6 (PAX6) is a powerful mediator of eye and brain organogenesis whose spatiotemporal expression is exquisitely controlled by multiple mechanisms, including post-transcriptional regulation by microRNAs (miRNAs). In the present study, we use bioinformatic predictions to identify three candidate microRNA-7 (miR-7) target sites in the human PAX6 3' untranslated region (3'-UTR) and demonstrate that two of them are functionally active in a human cell line. Furthermore, transient tra ...[more]
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