Insulin-Based Regulation of Glucose-functionalized Nanoparticle Uptake in Muscle Cells.
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ABSTRACT:
SUBMITTER: Yeh YC
PROVIDER: S-EPMC4116632 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Insulin-Based Regulation of Glucose-functionalized Nanoparticle Uptake in Muscle Cells.
Yeh Yi-Cheun YC Kim Sung Tae ST Tang Rui R Yan Bo B Rotello Vincent M VM
Journal of materials chemistry. B 20140501
Effective regulation of nanoparticle (NP) uptake facilitates the NP-based therapeutics and diagnostics. Here, we report the use of insulin and 2-deoxyglucose (2-DG) to modulate the cellular uptake of glucose-functionalized quantum dots (Glc-QDs) in C2C12 muscle cells. The cellular uptake of Glc-QDs can be modulated up to almost two-fold under insulin stimulation while be down-regulated in the presence of 2-DG. These results demonstrate the use of secondary regulators to control the cellular upta ...[more]
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