Ontology highlight
ABSTRACT:
SUBMITTER: Yuan X
PROVIDER: S-EPMC4116680 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Yuan Xiguo X Zhang Junying J Wang Yue Y
Biochemical genetics 20110114 5-6
Existing simulation methods usually simulate linkage disequilibrium (LD) structures starting with an initial population that is randomly generated according to specified allele frequencies. These at random based methods might be unstable because the LD level of the initial population is generally extremely low. This study presents a new algorithm, SIMLD, to simulate genome populations with real LD structures. SIMLD begins from an initial population with possibly the highest LD level, and then th ...[more]